Clinical-stage precision oncology company developing therapies targeting frontier oncology targets.
Revolution Medicines, Inc. is a pioneering clinical-stage precision oncology company at the forefront of developing innovative therapies aimed at inhibiting critical targets in RAS-addicted cancers. Founded in 2014 and headquartered in Redwood City, California, the company is dedicated to advancing treatments that address significant unmet needs in cancer therapy.
Central to Revolution Medicines' pipeline is RMC-4630, an inhibitor targeting SHP2 currently undergoing Phase 1/2 clinical trials. This therapy is designed to treat a variety of solid tumors, including gynecologic and colorectal cancers, marking a significant advancement in the field of precision oncology. Additionally, the company is developing RMC-5845, a selective inhibitor targeting SOS1, a crucial protein involved in activating RAS signaling pathways.
Revolution Medicines also focuses on RMC-5552, a hyperactivated selective inhibitor targeting mTORC1 signaling in tumors. Moreover, the company is advancing RMC-6291, a mutant-selective inhibitor targeting KRASG12C(ON) and NRASG12C(ON), along with RMC-6236, a RAS-selective inhibitor targeting multiple RAS(ON) variants. These efforts underscore the company's commitment to developing comprehensive therapeutic solutions for RAS-driven cancers.
In collaboration with Sanofi, Revolution Medicines has established a strategic agreement to research and develop SHP2 inhibitors, including RMC-4630, further enhancing its capabilities and expanding therapeutic opportunities. With a robust pipeline and a collaborative approach to innovation, Revolution Medicines continues to redefine the landscape of precision oncology, aiming to improve outcomes for cancer patients globally.