Develops cell therapies for inflammatory and immune-mediated diseases, focusing on regenerative medicine and tissue repair.
Mesoblast Limited is a pioneering company based in Melbourne, Australia, specializing in the development of regenerative medicine products that address a wide spectrum of medical conditions. Operating globally across Australia, the United States, Singapore, the United Kingdom, and Switzerland, Mesoblast focuses on therapeutic areas including cardiovascular diseases, spine orthopedic disorders, oncology, hematology, and immune-mediated and inflammatory diseases. At the heart of its innovation is a proprietary regenerative medicine technology platform centered on mesenchymal lineage cells, known for their therapeutic potential.
The company's flagship product, Remestemcel-L, is currently undergoing Phase III clinical trials for systemic inflammatory diseases such as steroid refractory acute graft versus host disease, acute respiratory distress syndrome, and biologic refractory inflammatory bowel disease. Additionally, Remestemcel-L is being evaluated in Phase III trials for chronic heart failure and chronic low back pain due to degenerative disc disease. Mesoblast is also advancing MPC-300-IV for biologic refractory rheumatoid arthritis and diabetic nephropathy, and MPC-25-IC for the treatment or prevention of acute myocardial infarction.
Mesoblast Limited has established strategic partnerships with key pharmaceutical companies, including Tasly Pharmaceutical Group for heart failure treatments in China, JCR Pharmaceuticals Co. Ltd. for wound healing in patients with epidermolysis bullosa, and Grünenthal for the development and commercialization of cell therapy targeting chronic low back pain. Since its incorporation in 2004, Mesoblast continues to lead the field of regenerative medicine, driving innovation and advancing therapies to improve patient outcomes worldwide.