Biopharmaceutical company developing RNA interference (RNAi) therapies for treating intractable diseases.
Arrowhead Pharmaceuticals, Inc. is dedicated to advancing therapeutic solutions for challenging diseases across the United States. The company's robust pipeline features a diverse array of RNA interference (RNAi) therapeutic candidates designed to address various unmet medical needs. Among its leading developments is ARO-AAT, currently in Phase II clinical trials for treating liver diseases associated with alpha-1 antitrypsin deficiency, showcasing Arrowhead's commitment to tackling rare genetic disorders.
Additionally, Arrowhead's pipeline includes promising candidates such as ARO-APOC3 and ARO-ANG3, both in advanced clinical stages targeting conditions like hypertriglyceridemia and dyslipidemia, respectively. ARO-HSD, having completed Phase 1/2 trials for liver diseases, underscores the company's dedication to expanding treatment options in this therapeutic area.
The company is also pioneering therapies like ARO-DUX4 for facioscapulohumeral muscular dystrophy and ARO-XDH for uncontrolled gout, highlighting its innovative approach to addressing complex diseases with high unmet needs. Furthermore, Arrowhead is actively engaged in developing potential treatments for COVID-19 with ARO-COV, and respiratory conditions with ARO-RAGE and ARO-MMP7, demonstrating its broad therapeutic focus.
Arrowhead Pharmaceuticals, Inc. has strategically partnered with industry leaders such as Janssen Pharmaceuticals, Inc. and Takeda Pharmaceuticals U.S.A., Inc. to accelerate the development of RNAi therapeutics. These collaborations underscore Arrowhead's collaborative approach in advancing novel treatments, leveraging its expertise in RNAi technology since its incorporation in 1989. Headquartered in Pasadena, California, Arrowhead Pharmaceuticals continues to drive innovation in biopharmaceuticals with a commitment to improving patient outcomes globally.